1. Oprah Winfrey and Gayle King
This forty-plus year friendship began when Oprah and Gayle were coworkers at a Baltimore TV station. The 22-year-old Winfrey invited 21-year-old King to stay with her during a sudden snowstorm and their tight bond has endured all manner of stormy weather since. They attribute the longevity of their rock-solid connection to mutual respect and unconditional love.